Article: Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Lau D; Vega-Saenz de Miera EC; Contreras D; Ozaita A; Harvey M; Chow A; Noebels JL; Paylor R; Morgan JI; Leonard CS; Rudy B J. Neurosci., 2000
Layer V–VI | Layer I–IV | |||||
---|---|---|---|---|---|---|
p | Wild-type n = 20 | Knock-out n = 20 | p | Wild-type n = 10 | Knock-out n = 10 | |
Resting V m(mV) | --- | −64.45 ± 0.54 | −63.60 ± 0.57 | --- | −64.22 ± 0.75 | −64.10 ± 0.60 |
R input(MΩ) | --- | 133.37 ± 6.19 | 142.42 ± 8.61 | --- | 153.50 ± 17.92 | 116.10 ± 8.60 |
Threshold (mV) | --- | −38.35 ± 0.59 | −38.81 ± 1.02 | --- | −37.04 ± 1.13 | −38.27 ± 0.67 |
Maximum rising slope (mV/msec) | --- | 155.54 ± 2.90 | 149.65 ± 8.04 | --- | 151.65 ± 6.33 | 165.36 ± 7.53 |
Maximum falling slope (mV/msec) | *** | −84.07 ± 1.84 | −61.11 ± 5.07 | --- | −79.37 ± 5.75 | −86.08 ± 4.75 |
Spike width at half amplitude (msec) | *** | 0.74 ± 0.018 | 0.94 ± 0.038 | --- | 0.78 ± 0.031 | 0.75 ± 0.036 |
AHP Amp (mV) | ** | 16.14 ± 0.68 | 12.34 ± 0.79 | --- | 17.64 ± 1.06 | 15.86 ± 0.69 |
AHP deceleration (mV/msec2) | *** | 133.88 ± 5.71 | 84.11 ± 7.34 | --- | 130.00 ± 8.63 | 135.96 ± 12.49 |
SS firing rate (Hz) | * | 152.11 ± 7.04 | 116.63 ± 10.21 | --- | 134.47 ± 7.52 | 155.21 ± 13.35 |
SS firing rate/initial frequency | ** | 0.85 ± 0.018 | 0.71 ± 0.031 | --- | 0.80 ± 0.023 | 0.83 ± 0.035 |
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FS cells are organized by the cortical layer in which they were found. Spike width, AHP, and slope measurements are from single action potentials. V m, Membrane potential;R input, input resistance of the cell; Amp, amplitude; SS, steady state. p values determined by Student's t test. *p < 0.01; **p < 0.001; ***p < 0.0001; dashed lines indicate non- significance (p > 0.05).